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Acute kidney injury (AKI) refers to the abnormality of kidney structure and function (including abnormal blood, urine, histology and imaging examination) within 3 months of disease course. resulting in clinical syndromes with different clinical manifestations.

In recent years, some new and more sensitive biomarkers of AKI have been discovered in clinical and laboratory studies, which can not only diagnose AKI before serum creatinine rises, but also provide help for the etiological diagnosis of AKI.

NGAL        The best index for early diagnosis of acute kidney injury

β2-MG      Monitoring indicators of proximal tubule function

MAU         Sensitive indicator of early or mild kidney injury

Microalbuminuria (MAU)

MAU is the most sensitive and reliable diagnostic indicator for early detection of renal disease. When the kidney is damaged, the urinary albumin excretion rate exceeds the normal range, which reflects the damage of glomerular filtration function and renal tubular reabsorption function. Combined with the incidence, symptoms and medical history statement, it can be more accurate to diagnose the condition.

Clinical significance: 

- Important indicators for early diagnosis of hypertension and diabetic nephropathy

- Early indications of changes in the kidneys and cardiovascular system

- Auxiliary diagnosis for glomerular injury

- Surveillance of pregnancy-induced hypertensive kidney injury

Applicable departments: 

Nephrology, emergency, interventional, ICU, cardiology, surgery